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KMID : 1140220230280020040
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대한암예방학회지
2023 Volume.28 No. 2 p.40 ~ p.46
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Baicalein Inhibits α-Melanocyte-stimulating Hormonestimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
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Oh Min-Chang
Pincha Devage Sameera Madushan Fernando
Mei Jing Piao
Kang Kyoung-Ah
Herath Mudiyanselage Udari lakmini Herath
Hyun Jin-Won
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Abstract
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Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
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KEYWORD
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α-Melanocyte-stimulating hormone, Baicalein, Carcinogenesis, Monophenol monooxygenase, B16F10 cells
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